Scudetto winners Roma and Napoli will meet in a Champions League quarter-final clash in Turin on Wednesday, while Lazio will be hoping to secure their place in next season’s Europa League after their defeat at Juventus on Wednesday.
The Roma-Milan encounter will be followed by the Milan-Lazio encounter on Tuesday, with a Milan-Napoli replay scheduled for Friday evening.
Roma face a Juventus side currently in the Europa League group stages, while Milan, who are currently bottom of Serie A, will be playing in the group stage for the first time since 2011.
Roma have won all three of their group-stage encounters so far, while Napoli are just one win away from their first consecutive Champions League berth in nine years.
Milan, meanwhile, were defeated 4-0 by Lazio on Wednesday in the opening round of the Champions League.
Lazio are currently third in Serie A with four games remaining.